Chemokine up-regulation in SARS-coronavirus -infected, monocyte-derived human dendritic cells
Identifieur interne : 004E60 ( Main/Exploration ); précédent : 004E59; suivant : 004E61Chemokine up-regulation in SARS-coronavirus -infected, monocyte-derived human dendritic cells
Auteurs : Helen K. W. Law [Hong Kong] ; CHUNG YAN CHEUNG ; HOI YEE NG ; SIN FUN SIA ; YUK ON CHAN ; Winsie Luk ; John M. Nicholls ; J. S. Malik Peiris ; YU LUNG LAUSource :
- Blood [ 0006-4971 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN (métabolisme), ARN viral (métabolisme), Activation enzymatique, Agranulocytes (cytologie), Amorces ADN (), Apoptose, Caspase-3, Caspases (biosynthèse), Cellules cultivées, Cellules dendritiques (cytologie), Chimiokine CCL2 (biosynthèse), Chimiokine CCL3, Chimiokine CCL4, Chimiokine CCL5 (biosynthèse), Chimiokines (biosynthèse), Cytokines (métabolisme), Cytométrie en flux, Facteurs temps, Humains, Inflammation, Interféron alpha (biosynthèse), Interféron bêta (biosynthèse), Interféron gamma (biosynthèse), Interleukine-12 (biosynthèse), Interleukine-12 (métabolisme), Interleukine-6 (biosynthèse), Microscopie de fluorescence, Microscopie électronique à transmission, Monocytes (cytologie), Protéines inflammatoires des macrophages (biosynthèse), RT-PCR, Réaction de polymérisation en chaîne, Régulation positive, Sous-unité p40 de l'interleukine-12, Sous-unités de protéines (biosynthèse), Séparation cellulaire, Technique d'immunofluorescence indirecte, Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- biosynthèse : Caspases, Chimiokine CCL2, Chimiokine CCL5, Chimiokines, Interféron alpha, Interféron bêta, Interféron gamma, Interleukine-12, Interleukine-6, Protéines inflammatoires des macrophages, Sous-unités de protéines.
- cytologie : Agranulocytes, Cellules dendritiques, Monocytes.
- génétique : Virus du SRAS.
- métabolisme : ARN, ARN viral, Cytokines, Interleukine-12, Virus du SRAS.
- Pascal (Inist)
- Activation enzymatique, Amorces ADN, Apoptose, Caspase-3, Cellules cultivées, Chimiokine, Chimiokine CCL3, Chimiokine CCL4, Coronavirus, Cellule infectée, Cytométrie en flux, Facteurs temps, Humains, Inflammation, Microscopie de fluorescence, Microscopie électronique à transmission, RT-PCR, Réaction de polymérisation en chaîne, Régulation positive, Sous-unité p40 de l'interleukine-12, Syndrome respiratoire aigu sévère, Monocyte, Homme, Cellule dendritique, Cellule APC, Immunosubversion, Réponse immune, Séparation cellulaire, Technique d'immunofluorescence indirecte.
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Antigen presenting cell, Apoptosis, Caspase 3, Caspases (biosynthesis), Cell Separation, Cells, Cultured, Chemokine, Chemokine CCL2 (biosynthesis), Chemokine CCL3, Chemokine CCL4, Chemokine CCL5 (biosynthesis), Chemokines (biosynthesis), Coronavirus, Cytokines (metabolism), DNA Primers (chemistry), Dendritic Cells (cytology), Dendritic cell, Enzyme Activation, Flow Cytometry, Fluorescent Antibody Technique, Indirect, Human, Humans, Immune evasion, Immune response, Infected cell, Inflammation, Interferon-alpha (biosynthesis), Interferon-beta (biosynthesis), Interferon-gamma (biosynthesis), Interleukin-12 (biosynthesis), Interleukin-12 (metabolism), Interleukin-12 Subunit p40, Interleukin-6 (biosynthesis), Leukocytes, Mononuclear (cytology), Macrophage Inflammatory Proteins (biosynthesis), Microscopy, Electron, Transmission, Microscopy, Fluorescence, Monocyte, Monocytes (cytology), Polymerase Chain Reaction, Protein Subunits (biosynthesis), RNA (metabolism), RNA, Viral (metabolism), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (metabolism), Severe acute respiratory syndrome, Time Factors, Up-Regulation.
- MESH :
- chemical , biosynthesis : Caspases, Chemokine CCL2, Chemokine CCL5, Chemokines, Interferon-alpha, Interferon-beta, Interferon-gamma, Interleukin-12, Interleukin-6, Macrophage Inflammatory Proteins, Protein Subunits.
- chemical , chemistry : DNA Primers.
- chemical , metabolism : Cytokines, Interleukin-12, RNA, RNA, Viral.
- chemical : Caspase 3, Chemokine CCL3, Chemokine CCL4, Interleukin-12 Subunit p40.
- cytology : Dendritic Cells, Leukocytes, Mononuclear, Monocytes.
- genetics : SARS Virus.
- metabolism : SARS Virus.
- Apoptosis, Cell Separation, Cells, Cultured, Enzyme Activation, Flow Cytometry, Fluorescent Antibody Technique, Indirect, Humans, Inflammation, Microscopy, Electron, Transmission, Microscopy, Fluorescence, Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Up-Regulation.
Abstract
Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we focused on dendritic cells (DCs) which play important roles in linking the innate and adaptive immunity. SARS-CoV was shown to infect both immature and mature human monocyte-derived DCs by electron microscopy and immunofluorescence. The detection of negative strands of SARS-CoV RNA in DCs suggested viral replication. However, no increase in viral RNA was observed. Using cytopathic assays, no increase in virus titer was detected in infected DCs and cell-culture supernatant, confirming that virus replication was incomplete. No induction of apoptosis or maturation was detected in SARS-CoV-infected DCs. The SARS-CoV-infected DCs showed low expression of antiviral cytokines (interferon a [IFN-a], IFN-β, IFN-γ, and interleukin 12p40 [IL-12p40]), moderate up-regulation of proinflammatory cytokines (tumor necrosis factor a [TNF-α] and IL-6) but significant up-regulation of inflammatory chemokines (macrophage inflammatory protein 1α [MIP-1α], regulated on activation normal T cell expressed and secreted [RANTES]), interferon-inducible protein of 10 kDa [IP-10], and monocyte chemo-attractant protein 1 [MCP-1]). The lack of antiviral cytokine response against a background of intense chemokine up-regulation could represent a mechanism of immune evasion by SARS-CoV.
Affiliations:
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Le document en format XML
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Law</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Paediatrics and Adolescent Medicine, the Department of Microbiology, and the Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Chung Yan Cheung" sort="Chung Yan Cheung" uniqKey="Chung Yan Cheung" last="Chung Yan Cheung">CHUNG YAN CHEUNG</name></author><author><name sortKey="Hoi Yee Ng" sort="Hoi Yee Ng" uniqKey="Hoi Yee Ng" last="Hoi Yee Ng">HOI YEE NG</name></author><author><name sortKey="Sin Fun Sia" sort="Sin Fun Sia" uniqKey="Sin Fun Sia" last="Sin Fun Sia">SIN FUN SIA</name></author><author><name sortKey="Yuk On Chan" sort="Yuk On Chan" uniqKey="Yuk On Chan" last="Yuk On Chan">YUK ON CHAN</name></author><author><name sortKey="Luk, Winsie" sort="Luk, Winsie" uniqKey="Luk W" first="Winsie" last="Luk">Winsie Luk</name></author><author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. 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W." last="Law">Helen K. W. Law</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Paediatrics and Adolescent Medicine, the Department of Microbiology, and the Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Chung Yan Cheung" sort="Chung Yan Cheung" uniqKey="Chung Yan Cheung" last="Chung Yan Cheung">CHUNG YAN CHEUNG</name></author><author><name sortKey="Hoi Yee Ng" sort="Hoi Yee Ng" uniqKey="Hoi Yee Ng" last="Hoi Yee Ng">HOI YEE NG</name></author><author><name sortKey="Sin Fun Sia" sort="Sin Fun Sia" uniqKey="Sin Fun Sia" last="Sin Fun Sia">SIN FUN SIA</name></author><author><name sortKey="Yuk On Chan" sort="Yuk On Chan" uniqKey="Yuk On Chan" last="Yuk On Chan">YUK ON CHAN</name></author><author><name sortKey="Luk, Winsie" sort="Luk, Winsie" uniqKey="Luk W" first="Winsie" last="Luk">Winsie Luk</name></author><author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name></author><author><name sortKey="Yu Lung Lau" sort="Yu Lung Lau" uniqKey="Yu Lung Lau" last="Yu Lung Lau">YU LUNG LAU</name></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen presenting cell</term><term>Apoptosis</term><term>Caspase 3</term><term>Caspases (biosynthesis)</term><term>Cell Separation</term><term>Cells, Cultured</term><term>Chemokine</term><term>Chemokine CCL2 (biosynthesis)</term><term>Chemokine CCL3</term><term>Chemokine CCL4</term><term>Chemokine CCL5 (biosynthesis)</term><term>Chemokines (biosynthesis)</term><term>Coronavirus</term><term>Cytokines (metabolism)</term><term>DNA Primers (chemistry)</term><term>Dendritic Cells (cytology)</term><term>Dendritic cell</term><term>Enzyme Activation</term><term>Flow Cytometry</term><term>Fluorescent Antibody Technique, Indirect</term><term>Human</term><term>Humans</term><term>Immune evasion</term><term>Immune response</term><term>Infected cell</term><term>Inflammation</term><term>Interferon-alpha (biosynthesis)</term><term>Interferon-beta (biosynthesis)</term><term>Interferon-gamma (biosynthesis)</term><term>Interleukin-12 (biosynthesis)</term><term>Interleukin-12 (metabolism)</term><term>Interleukin-12 Subunit p40</term><term>Interleukin-6 (biosynthesis)</term><term>Leukocytes, Mononuclear (cytology)</term><term>Macrophage Inflammatory Proteins (biosynthesis)</term><term>Microscopy, Electron, Transmission</term><term>Microscopy, Fluorescence</term><term>Monocyte</term><term>Monocytes (cytology)</term><term>Polymerase Chain Reaction</term><term>Protein Subunits (biosynthesis)</term><term>RNA (metabolism)</term><term>RNA, Viral (metabolism)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Severe acute respiratory syndrome</term><term>Time Factors</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN (métabolisme)</term><term>ARN viral (métabolisme)</term><term>Activation enzymatique</term><term>Agranulocytes (cytologie)</term><term>Amorces ADN ()</term><term>Apoptose</term><term>Caspase-3</term><term>Caspases (biosynthèse)</term><term>Cellules cultivées</term><term>Cellules dendritiques (cytologie)</term><term>Chimiokine CCL2 (biosynthèse)</term><term>Chimiokine CCL3</term><term>Chimiokine CCL4</term><term>Chimiokine CCL5 (biosynthèse)</term><term>Chimiokines (biosynthèse)</term><term>Cytokines (métabolisme)</term><term>Cytométrie en flux</term><term>Facteurs temps</term><term>Humains</term><term>Inflammation</term><term>Interféron alpha (biosynthèse)</term><term>Interféron bêta (biosynthèse)</term><term>Interféron gamma (biosynthèse)</term><term>Interleukine-12 (biosynthèse)</term><term>Interleukine-12 (métabolisme)</term><term>Interleukine-6 (biosynthèse)</term><term>Microscopie de fluorescence</term><term>Microscopie électronique à transmission</term><term>Monocytes (cytologie)</term><term>Protéines inflammatoires des macrophages (biosynthèse)</term><term>RT-PCR</term><term>Réaction de polymérisation en chaîne</term><term>Régulation positive</term><term>Sous-unité p40 de l'interleukine-12</term><term>Sous-unités de protéines (biosynthèse)</term><term>Séparation cellulaire</term><term>Technique d'immunofluorescence indirecte</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Caspases</term><term>Chemokine CCL2</term><term>Chemokine CCL5</term><term>Chemokines</term><term>Interferon-alpha</term><term>Interferon-beta</term><term>Interferon-gamma</term><term>Interleukin-12</term><term>Interleukin-6</term><term>Macrophage Inflammatory Proteins</term><term>Protein Subunits</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA Primers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Interleukin-12</term><term>RNA</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Caspase 3</term><term>Chemokine CCL3</term><term>Chemokine CCL4</term><term>Interleukin-12 Subunit p40</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Caspases</term><term>Chimiokine CCL2</term><term>Chimiokine CCL5</term><term>Chimiokines</term><term>Interféron alpha</term><term>Interféron bêta</term><term>Interféron gamma</term><term>Interleukine-12</term><term>Interleukine-6</term><term>Protéines inflammatoires des macrophages</term><term>Sous-unités de protéines</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term><term>Cellules dendritiques</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dendritic Cells</term><term>Leukocytes, Mononuclear</term><term>Monocytes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN</term><term>ARN viral</term><term>Cytokines</term><term>Interleukine-12</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term><term>Cell Separation</term><term>Cells, Cultured</term><term>Enzyme Activation</term><term>Flow Cytometry</term><term>Fluorescent Antibody Technique, Indirect</term><term>Humans</term><term>Inflammation</term><term>Microscopy, Electron, Transmission</term><term>Microscopy, Fluorescence</term><term>Polymerase Chain Reaction</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Up-Regulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Activation enzymatique</term><term>Amorces ADN</term><term>Apoptose</term><term>Caspase-3</term><term>Cellules cultivées</term><term>Chimiokine</term><term>Chimiokine CCL3</term><term>Chimiokine CCL4</term><term>Coronavirus</term><term>Cellule infectée</term><term>Cytométrie en flux</term><term>Facteurs temps</term><term>Humains</term><term>Inflammation</term><term>Microscopie de fluorescence</term><term>Microscopie électronique à transmission</term><term>RT-PCR</term><term>Réaction de polymérisation en chaîne</term><term>Régulation positive</term><term>Sous-unité p40 de l'interleukine-12</term><term>Syndrome respiratoire aigu sévère</term><term>Monocyte</term><term>Homme</term><term>Cellule dendritique</term><term>Cellule APC</term><term>Immunosubversion</term><term>Réponse immune</term><term>Séparation cellulaire</term><term>Technique d'immunofluorescence indirecte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we focused on dendritic cells (DCs) which play important roles in linking the innate and adaptive immunity. SARS-CoV was shown to infect both immature and mature human monocyte-derived DCs by electron microscopy and immunofluorescence. The detection of negative strands of SARS-CoV RNA in DCs suggested viral replication. However, no increase in viral RNA was observed. Using cytopathic assays, no increase in virus titer was detected in infected DCs and cell-culture supernatant, confirming that virus replication was incomplete. No induction of apoptosis or maturation was detected in SARS-CoV-infected DCs. The SARS-CoV-infected DCs showed low expression of antiviral cytokines (interferon a [IFN-a], IFN-β, IFN-γ, and interleukin 12p40 [IL-12p40]), moderate up-regulation of proinflammatory cytokines (tumor necrosis factor a [TNF-α] and IL-6) but significant up-regulation of inflammatory chemokines (macrophage inflammatory protein 1α [MIP-1α], regulated on activation normal T cell expressed and secreted [RANTES]), interferon-inducible protein of 10 kDa [IP-10], and monocyte chemo-attractant protein 1 [MCP-1]). The lack of antiviral cytokine response against a background of intense chemokine up-regulation could represent a mechanism of immune evasion by SARS-CoV.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country></list><tree><noCountry><name sortKey="Chung Yan Cheung" sort="Chung Yan Cheung" uniqKey="Chung Yan Cheung" last="Chung Yan Cheung">CHUNG YAN CHEUNG</name><name sortKey="Hoi Yee Ng" sort="Hoi Yee Ng" uniqKey="Hoi Yee Ng" last="Hoi Yee Ng">HOI YEE NG</name><name sortKey="Luk, Winsie" sort="Luk, Winsie" uniqKey="Luk W" first="Winsie" last="Luk">Winsie Luk</name><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J. S. Malik" last="Peiris">J. S. Malik Peiris</name><name sortKey="Sin Fun Sia" sort="Sin Fun Sia" uniqKey="Sin Fun Sia" last="Sin Fun Sia">SIN FUN SIA</name><name sortKey="Yu Lung Lau" sort="Yu Lung Lau" uniqKey="Yu Lung Lau" last="Yu Lung Lau">YU LUNG LAU</name><name sortKey="Yuk On Chan" sort="Yuk On Chan" uniqKey="Yuk On Chan" last="Yuk On Chan">YUK ON CHAN</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Law, Helen K W" sort="Law, Helen K W" uniqKey="Law H" first="Helen K. W." last="Law">Helen K. W. Law</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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